A 2023 law championed by Republicans requires the CDC have a director confirmed by the Senate. For months, though, it's had only acting directors--and the White House won't say when that will change. As the agency rotates through a cast of leaders, it's unclear when--or if--the US Centers for Disease Control and Prevention will get a permanent director under Donald Trump's second term as president. Following Jim O'Neill's departure as acting CDC director last week, National Institutes of Health director Jay Bhattacharya will now lead both agencies temporarily. It's the latest in a series of shakeups at Trump's CDC, which has lost about a quarter of its staff to mass layoffs carried out by Health and Human Services Secretary Robert F. Kennedy, Jr. last year.

We present an alternative approach to decompose non-negative tensors, called many-body approximation .

Chronic Kidney Disease (CKD) constitutes a major global medical burden, marked by the gradual deterioration of renal function, which results in the impaired clearance of metabolic waste and disturbances in systemic fluid homeostasis. Owing to its substantial contribution to worldwide morbidity and mortality, the development of reliable and efficient diagnostic approaches is critically important to facilitate early detection and prompt clinical management. This study presents a deep convolutional neural network (CNN) for early CKD detection from CT kidney images, complemented by class balancing using Synthetic Minority Over-sampling Technique (SMOTE) and interpretability via Gradient-weighted Class Activation Mapping (Grad-CAM). The model was trained and evaluated on the CT KIDNEY DATASET, which contains 12,446 CT images, including 3,709 cyst, 5,077 normal, 1,377 stone, and 2,283 tumor cases. The proposed deep CNN achieved a remarkable classification performance, attaining 100% accuracy in the early detection of chronic kidney disease (CKD). This significant advancement demonstrates strong potential for addressing critical clinical diagnostic challenges and enhancing early medical intervention strategies.

With the rapid advancement of conversational and diffusion-based AI, there is a growing adoption of AI in educational services, ranging from grading and assessment tools to personalized learning systems that provide targeted support for students. However, this adaptability has yet to fully extend to the domain of children's speech, where existing models often fail due to their reliance on datasets designed for clear, articulate adult speech. Children, particularly those in early developmental stages or with speech and language pathologies, present unique challenges that current AI models and datasets are ill-equipped to handle. To address this, we introduce KidSpeak, a multi-task speech-enhanced Foundation Model capable of both generative and discriminative tasks specifically tailored to children's speech patterns. Our framework employs a two-stage training process that incorporates phonetic knowledge into the speech encoder, achieving an average accuracy of 87% across four separate tasks. Furthermore, recognizing the limitations of scalable human annotation and existing speech alignment tools, we propose the Flexible and Automatic Speech Aligner (F ASA) and leverage the method to construct high quality datasets for training and evaluation. This novel alignment tool significantly improves the quality of aligned children's speech from noisy data, enhancing data quality by 13.6 compared to human annotations, as demonstrated on the CHILDES dataset. To the best of our knowledge, KidSpeak and F ASA represent the first comprehensive solution designed for speech and language therapy in children, offering both a multi-purpose speech LLM and a robust alignment tool.

OpenAI CEO Sam Altman scrambles to boost ChatGPT's quality and first lady Melania Trump rolls out an AI-powered Spanish translation of her memoir.

Multimodal (MM) learning is emerging as a promising paradigm in biomedical artificial intelligence (AI) applications, integrating complementary modality, which highlight different aspects of patient health. The scarcity of large heterogeneous biomedical MM data has restrained the development of robust models for medical AI applications. In the dermatology domain, for instance, skin lesion datasets typically include only images linked to minimal metadata describing the condition, thereby limiting the benefits of MM data integration for reliable and generalizable predictions. Recent advances in Large Language Models (LLMs) enable the synthesis of textual description of image findings, potentially allowing the combination of image and text representations. However, LLMs are not specifically trained for use in the medical domain, and their naive inclusion has raised concerns about the risk of hallucinations in clinically relevant contexts. This work investigates strategies for generating synthetic textual clinical notes, in terms of prompt design and medical metadata inclusion, and evaluates their impact on MM architectures toward enhancing performance in classification and cross-modal retrieval tasks. Experiments across several heterogeneous dermatology datasets demonstrate that synthetic clinical notes not only enhance classification performance, particularly under domain shift, but also unlock cross-modal retrieval capabilities, a downstream task that is not explicitly optimized during training.

Traditional threat modeling remains reactive-focused on known TTPs and past incident data, while threat prediction and forecasting frameworks are often disconnected from operational or architectural artifacts. This creates a fundamental weakness: the most serious cyber threats often do not arise from what is known, but from what is assumed, overlooked, or not yet conceived, and frequently originate from the future, such as artificial intelligence, information warfare, and supply chain attacks, where adversaries continuously develop new exploits that can bypass defenses built on current knowledge. To address this mental gap, this paper introduces the theory and methodology of Future-Back Threat Modeling (FBTM). This predictive approach begins with envisioned future threat states and works backward to identify assumptions, gaps, blind spots, and vulnerabilities in the current defense architecture, providing a clearer and more accurate view of impending threats so that we can anticipate their emergence and shape the future we want through actions taken now. The proposed methodology further aims to reveal known unknowns and unknown unknowns, including tactics, techniques, and procedures that are emerging, anticipated, and plausible. This enhances the predictability of adversary behavior, particularly under future uncertainty, helping security leaders make informed decisions today that shape more resilient security postures for the future.

We study robust subspace estimation in the streaming and distributed settings.

Submodular functions are heavily studied in a wide variety of disciplines since they are used to model many real world phenomena and are amenable to optimization.